2019-11-19
Langener Wissenschaftspreisträgerin 2019: Prof. Daniela Krause erforscht das Mikromilieu des Knochenmarks als Angriffspunkt für neue Therapien gegen Blutkrebs
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Pressemeldungen
Publications
- RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma
PubMed - Axes of biological variation in diffuse large B cell lymphoma
PubMed - Time to coronary angiography and revascularization in 575,247 patients with STEMI from 2012 to 2023: a retrospective population-based cohort study
PubMed - Functional connectivity in electroencephalography of brain tumor patients in status epilepticus: a retrospective evaluation of prognostic value
PubMed - New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti-Tumor Activity Against Ewing Sarcoma
PubMed - Author Correction: Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
PubMed - PET/CT-guided management of immune checkpoint blockade and multi-modal profiling following treatment in long-term responders with metastatic lung cancer in the National Network Genomic Medicine Lung Cancer Germany (nNGM)
PubMed - p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism
PubMed - Engineering with care: safety assessment platforms for CRISPR-modified natural killer cells
PubMed - Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation
PubMed - Publisher Correction: State of the art: glioma-associated epilepsy-bridging tumor biology and epileptogenesis
PubMed - A phase III placebo-controlled study of eftilagimod alfa plus pembrolizumab and chemotherapy in metastatic non-small cell lung cancer
PubMed - ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer
PubMed - Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
PubMed - Fura-10, unlike fura-2, is suitable for long-term calcium imaging in natural killer (NK) cells without compromising cytotoxicity and can be combined with target cell death analysis
PubMed - Ferroptosis Enhances T Lymphocyte Infiltration into Glioblastoma Spheroids
PubMed - Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas
PubMed - Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells
PubMed - Study design and rationale for the NeoTRACE trial: a multicenter phase II study of neoadjuvant sacituzumab govitecan plus zimberelimab followed by adjuvant zimberelimab with or without sacituzumab govitecan in patients with resectable non-small cell lung cancer
PubMed - A masking clamp for conditional activation of therapeutic antibodies
PubMed - Allele-specific immune gene quantification and expression analysis in single-cell RNA-seq data
PubMed - ApoE2-DARPin fusion proteins enable selective RNA transfer to CD8 T cells by lipid nanoparticles
PubMed - Impact of preoperative clinical patient parameters on surgically obtained brain metastasis samples for translational research
PubMed - HDR Mould-Based Brachytherapy for Cutaneous Neoplasms: Toxicity, Long-Term Control, Cosmesis and PROMs
PubMed - Lung endothelial PEAR1 induces tumor cell dormancy
PubMed - Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
PubMed - Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
PubMed - Rethinking survival metrics in EGFR-mutated NSCLC: insights from RMST analysis of FLAURA2 and MARIPOSA
PubMed - Measurable residual disease-guided interventions in patients with acute myeloid leukaemia undergoing allogeneic haematopoietic cell transplantation: best practice recommendations from the European Society for Blood and Marrow Transplantation Practice Harmonisation and Guidelines Committee
PubMed - Targeting Mutual Dependence of Phosphatidylinositol-3-Kinase α/δ and Small Ubiquitin-Like Modifier Signaling in Pancreatic Cancer
PubMed - Quality of life following total neoadjuvant therapy for rectal cancer
PubMed - Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures
PubMed - A Chemically Induced CRISPR/dCas13FCPF Platform for Precise and Programmable RNA Regulation
PubMed - Insights, opportunities, and challenges provided by large cell atlases
PubMed - Outcomes at Patient and Limb Levels in Peripheral Artery Disease by the Location of Atherosclerotic Lower Limb Lesions: An Observational Study from a High-Volume German Center
PubMed - Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer - A multicenter analysis of early outcomes and toxicity
PubMed - State of the art: glioma-associated epilepsy-bridging tumor biology and epileptogenesis
PubMed - Glioma‑associated microglia and macrophages as a potential target for mTOR inhibition in glioblastoma
PubMed - Current and emerging concepts for systemic treatment of metastatic colorectal cancer
PubMed - Hypomethylating Therapy With or Without Eltrombopag in Elderly Patients With Acute Myeloid Leukemia: Results From the Randomized, Placebo-Controlled Phase 2 DELTA Trial
PubMed - In vivo chimeric antigen receptor (CAR)-T cell therapy
PubMed - Metabolic Implications of Efferocytosis During Inflammation
PubMed - The immune microenvironment of colorectal cancer
PubMed - Building a transparent and functional laboratory culture: guidelines for creating a Laboratory Handbook for principal investigators
PubMed - Clonal evolution and apoptosis resistance in myelodysplastic neoplasms and acute myeloid leukemia under treatment: insights from integrative longitudinal profiling
PubMed - Restoring NK Cell Cytotoxicity Post-Cryopreservation via Synthetic Cells
PubMed - FACS-Based Assessment of Human Hematopoietic Stem and Progenitor Cells
PubMed - A pooled analysis of 3 large multicenter trials confirms a survival advantage for NPM1 mut AML in MRDneg remission after intensive induction
PubMed - DNA methylation-based profiling is an effective asset for identification of tumors in suspected, yet immunohistochemically, unspecified neuro-oncological cases
PubMed - DNA methylation analysis reveals an epigenetic signature distinctive of high-grade oligodendroglioma
PubMed - A data-driven algorithm to determine 1H-MRS basis set composition
PubMed - Absolute quantification of cerebral metabolites using two-dimensional proton MR spectroscopic imaging with quantitative MRI-based water reference
PubMed - Chromatin Perturbation Promotes Susceptibility to Hypomethylating Agents
PubMed - Distress screening in patients with high-grade glioma: diagnostic accuracy in relation to a structured clinical interview in a multicenter cluster-randomized controlled trial
PubMed - Immunoregulatory Endothelial Cells Interact With T Cells After Myocardial Infarction
PubMed - The transcriptomic signature of DEPDC5 KO induced mTOR hyperactivation in human neurons and its response to rapamycin treatment
PubMed - Macrophage fatty acid metabolism under chronic hypoxia shapes γδ T cell recruitment via CCL22
PubMed - Learning interpretable representations of single-cell multi-omics data with multi-output Gaussian processes
PubMed - Multi-site feasibility and reproducibility study on UTE 3D phosphorous MRSI using novel rosette trajectory (PETALUTE)
PubMed - Distinct molecular profile and outcome of oligodendroglioma, IDH-mutant, 1p/19q-codeleted, and TERTp-wildtype: A grade 1 oligodendroglioma of young patients?
PubMed - Genetic lesions in nodular lymphocyte-predominant Hodgkin lymphoma and T cell/histiocyte-rich large B-cell lymphoma identified by whole genome sequencing
PubMed - Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells
PubMed - Lossy DICOM conversion may affect AI performance
PubMed - Precision targeting of rhabdomyosarcoma by combining primary CAR NK cells and radiotherapy
PubMed - Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes
PubMed - Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase
PubMed - Impact of tumor size and peritumoral edema on outcomes and complications in anterior midline skull base meningiomas
PubMed - No evidence of leukaemia (NEL) as a response criteria in paediatric AML: a multicentre analysis
PubMed - Crystallographic fragment screening reveals ligand hotspots in TRIM21 PRY-SPRY domain
PubMed - CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma
PubMed - BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma
PubMed - Outcome-associated factors in a molecularly defined cohort of central neurocytoma
PubMed - crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors
PubMed - The tumor suppressor FAT1 controls YAP/TAZ protein degradation and tumor cell proliferation through E3 ligase MIB2
PubMed - Chimeric antigen receptor NK-92 cell function is modulated by HLA class I expression of target cells
PubMed - Strategies for CRISPR-based knock-ins in primary human B cells and lymphoma cell lines
PubMed - AI in optimized cancer treatment: laying the groundwork for interdisciplinary progress
PubMed - Quality of Life After Two Sequences of Total Neoadjuvant Treatment in Patients With Locally Advanced Rectal Cancer in the Randomized CAO/ARO/AIO-12 Phase 2 Trial
PubMed - The role of the extracellular matrix protein SPOCK2 for bone physiology and hematopoiesis
PubMed - Large vesicles from ageing neutrophils: novel safeguards for the resolution of inflammation
PubMed - Immune responses after one versus two Influenza A/B vaccinations in patients with multiple myeloma
PubMed - Emerging advances and future opportunities in the molecular and therapeutic landscape of anal cancer
PubMed - Overexpression of KMT9α is associated with poor outcome in cholangiocarcinoma patients
PubMed - Organ preservation after total neoadjuvant therapy for locally advanced rectal cancer (CAO/ARO/AIO-16): an open-label, multicentre, single-arm, phase 2 trial
PubMed - S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation
PubMed - Oncogene aberrations drive medulloblastoma progression, not initiation
PubMed - Native Taylor/Non-Taylor Dispersion-Mass Spectrometry (TNT-MS) Allows Rapid Protein Desalting and Multiplexed, Label-Free Ligand Screening
PubMed - Native Flow-Induced Dispersion Analysis - Mass Spectrometry Enables Automated, Multiplexed Ligand Screening from Conventional, Nonvolatile Buffers
PubMed - Identification and characterization of tertiary lymphoid structures in brain metastases
PubMed - Determination of Minimum Surgical Caseloads for Major Oncologic Resections Using a Population-Attributable Fraction Model of Observational Data in Germany
PubMed - ErbB2/HER2-targeted CAR-NK cells eliminate breast cancer cells in an organoid model that recapitulates tumor progression
PubMed - ACO/ARO/AIO-22 - External beam radiotherapy combined with endorectal high-dose-rate brachytherapy in elderly and frail patients with rectal cancer: A prospective multicentre trial of the German Rectal Cancer Study Group
PubMed - Premature skeletal muscle aging in VPS13A deficiency relates to impaired autophagy
PubMed - Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes
PubMed - Endorectal brachytherapy for organ preservation in patients with rectal cancer: A paradigm shift?
PubMed - Optimized Long-TE 1H sLASER MR Spectroscopic Imaging at 3T for Separate Quantification of Glutamate and Glutamine in Glioma
PubMed - Inflammatory signaling pathways play a role in SYK inhibitor resistant AML
PubMed - Epidemiology and outcomes of Candida spp. bloodstream infections in cancer patients: a comparative retrospective study from a German tertiary cancer center
PubMed - Migration Dynamics of Human NK Cell Preparations in Microchannels and Their Invasion Into Patient-Derived Tissue
PubMed - Neoadjuvant chemoradiation for patients with resectable locally advanced oral cavity squamous cell carcinoma: Results of the prospective INVERT clinical trial
PubMed