2024-07-09
Factor in connective tissue cells (ZEB1) modulates the efficacy of immunotherapy in colorectal carcinomas
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2024-03-22
New Research Results – Safety of Short-Term Cultivated CAR T Cells in Cancer Immunotherapy
To the article2024-02-01
The German Science and Humanities Council (Wissenschaftsrat) attests the Georg-Speyer-Haus “Impressive contributions to tumor research”
To the articlePublications
- BRAT1 - a new therapeutic target for glioblastoma
PubMed - Impact of inhibitory KIR ligand mismatch and other variables on outcomes following myeloablative posttransplant cyclophosphamide-based T-cell-replete haploidentical bone marrow transplantation
PubMed - Expression of claudin-18.2 in cholangiocarcinoma: a comprehensive immunohistochemical analysis from a German tertiary centre
PubMed - Towards interactive AI-authoring with prototypical few-shot classifiers in histopathology
PubMed - Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
PubMed - DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma
PubMed - Impaired SARS-CoV-2-Specific CD8+ T Cells After Infection or Vaccination but Robust Hybrid T Cell Immunity in Patients with Multiple Myeloma
PubMed - EANO guideline on molecular testing of meningiomas for targeted therapy selection
PubMed - Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients
PubMed - An AMP-activated protein kinase-PGC-1α axis mediates metabolic plasticity in glioblastoma
PubMed - Establishment of Patient-Derived Organoids from Colorectal Cancer Resection Samples
PubMed - Tumor Response and Its Impact on Treatment Failure in Rectal Cancer: Does Intensity of Neoadjuvant Treatment Matter?
PubMed - Mapping Natural Sugars Metabolism in Acute Myeloid Leukaemia Using 2D Nuclear Magnetic Resonance Spectroscopy
PubMed - Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies
PubMed - A fast protocol for multicenter and multiparametric quantitative MRI studies in brain tumor patients using vendor sequences
PubMed - Gut microbial carcinogen metabolism: another avenue to cancer
PubMed - Pathological tissue changes in brain tumors affect the pH-sensitivity of the T1-corrected apparent exchange dependent relaxation (AREX) of the amide protons
PubMed - Phosphoproteomic Analysis of Signaling Pathways in Lymphomas
PubMed - Updated EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection - Update 1
PubMed - Transglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway
PubMed - Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4
PubMed - Inflammation in a ferroptotic environment
PubMed - EZB-type diffuse large B-cell lymphoma cell lines have superior migration capabilities compared to MCD-type
PubMed - CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells
PubMed - CD16+ as predictive marker for early relapse in aggressive B-NHL/DLBCL patients
PubMed - The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection
PubMed - Dual Centrifugation-Based Screening for pH-Responsive Liposomes
PubMed - Irradiation alters extracellular vesicle microRNA load in the serum of patients with leukaemia
PubMed - Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing
PubMed - Data-driven determination of 1H-MRS basis set composition
PubMed - In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma
PubMed - RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions
PubMed - Bispecific killer cell engagers employing species cross-reactive NKG2D binders redirect human and murine lymphocytes to ErbB2/HER2-positive malignancies
PubMed - Persistent Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Rectal Cancer
PubMed - mFOLFOX6 versus mFOLFOX6 + aflibercept as neoadjuvant treatment in MRI-defined T3-rectal cancer: a randomized phase-II-trial of the German Rectal Cancer Study Group (CAO/ARO/AIO 0214)
PubMed - Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
PubMed - Imperative role of adaptor proteins in macrophage toll-like receptor signaling pathways
PubMed - Interventional antibiotic treatment replacing antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation is safe and leads to a reduction of antibiotic administration
PubMed - Editorial: Women in cancer immunity and immunotherapy
PubMed - Cell blebbing novel therapeutic possibilities to counter metastasis
PubMed - Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy
PubMed - Amino acid metabolism in glioma: in vivo MR-spectroscopic detection of alanine as a potential biomarker of poor survival in glioma patients
PubMed - Superoxide dismutase 1 mediates adaptation to the tumor microenvironment of glioma cells via mammalian target of rapamycin complex 1
PubMed - Survival probability of epigenetically defined IDH-wild-type glioblastoma without necrosis or vascular proliferation
PubMed - Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials
PubMed - Epigenetic profiling of prostate cancer reveals potential prognostic signatures
PubMed - T cell receptor-directed antibody-drug conjugates for the treatment of T cell-derived cancers
PubMed - Immune profiling and functional analysis of NK and T cells in ataxia telangiectasia
PubMed - Diagnosis of Hirschsprung disease by analyzing acetylcholinesterase staining using artificial intelligence
PubMed - T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8
PubMed - Cranioencephalic functional lymphoid units in glioblastoma
PubMed - Corrigendum: Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells
PubMed - Small duct and large duct type intrahepatic cholangiocarcinoma reveal distinct patterns of immune signatures
PubMed - Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations
PubMed - Targeting the Sodium-Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
PubMed - Real-world effectiveness of first-line azacitidine or decitabine with or without venetoclax in acute myeloid leukemia patients unfit for intensive therapy
PubMed - Systemic Treatment of Recurrent Hepatocellular Carcinoma after Liver Transplantation: A Multicenter Trial
PubMed - (Auto)immunity in focal epilepsy: mechanisms of (auto‑)immune-inflammatory epileptogenic neurodegeneration
PubMed - ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer
PubMed - A Mouse Model of X-Linked Chronic Granulomatous Disease for the Development of CRISPR/Cas9 Gene Therapy
PubMed - Development of a Potent and Selective G2A (GPR132) Agonist
PubMed - Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B
PubMed - Tumour-specific activation of a tumour-blood transport improves the diagnostic accuracy of blood tumour markers in mice
PubMed - Disturbance in cerebral blood microcirculation and hypoxic-ischemic microenvironment are associated with the development of brain metastasis
PubMed - Empowering virus-free CAR immune cell therapies
PubMed - Long-wavelength traveling waves of vasomotion modulate the perfusion of cortex
PubMed - A prognostic neural epigenetic signature in high-grade glioma
PubMed - Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors
PubMed - Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
PubMed - 2D 1H sLASER Long-TE and 3D 31P Chemical Shift Imaging at 3 T for Monitoring Fasting-Induced Changes in Brain Tumor Tissue
PubMed - Bortezomib promotes the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/Her2-targeted CAR-NK-92 cells via DR5 upregulation
PubMed - Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
PubMed - Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
PubMed - Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma
PubMed - Nanopore sequencing from formalin-fixed paraffin-embedded specimens for copy-number profiling and methylation-based CNS tumor classification
PubMed - Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
PubMed - Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
PubMed - Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging
PubMed - Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
PubMed - Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)
PubMed - Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress
PubMed - EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
PubMed - Phosphatidylserine externalization as immune checkpoint in cancer
PubMed - Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study
PubMed - Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models
PubMed - Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche
PubMed - Feasibility of Next-generation Sequencing of Liquid Biopsy (Circulating Tumor DNA) Samples and Tumor Tissue from Patients with Metastatic Prostate Cancer in a Real-world Clinical Setting in Germany
PubMed - Future direction of total neoadjuvant therapy for locally advanced rectal cancer
PubMed - Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look
PubMed - Evolutionary trajectories of small cell lung cancer under therapy
PubMed - Epigenetic control over the cell-intrinsic immune response antagonizes self-renewal in acute myeloid leukemia
PubMed - Fluorescence confocal microscopy-complete digitization of pathology
PubMed - A guideline on the molecular ecosystem regulating ferroptosis
PubMed - Deep-learning-based reconstruction of undersampled MRI to reduce scan times: a multicentre, retrospective, cohort study
PubMed - Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors
PubMed - PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle
PubMed - CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation
PubMed - Digital Pathology
PubMed - Heterogeneity of small duct- and large duct-type intrahepatic cholangiocarcinoma
PubMed - miR-147b mediated suppression of DUSP8 promotes lung cancer progression
PubMed