2025-03-27
Announcement of the Langen Science Award
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Press Releases
2025-03-01
A Surprising Shift from Foe to Friend: Researchers discover dual role of inflammatory signaling in colorectal cancer
To the article2024-07-09
Factor in connective tissue cells (ZEB1) modulates the efficacy of immunotherapy in colorectal carcinomas
To the articlePublications
- Overexpression of KMT9α is associated with poor outcome in cholangiocarcinoma patients
PubMed - Organ preservation after total neoadjuvant therapy for locally advanced rectal cancer (CAO/ARO/AIO-16): an open-label, multicentre, single-arm, phase 2 trial
PubMed - S1PR4-dependent effects of Etrasimod on primary human myeloid immune cell activation
PubMed - Oncogene aberrations drive medulloblastoma progression, not initiation
PubMed - Native Taylor/Non-Taylor Dispersion-Mass Spectrometry (TNT-MS) Allows Rapid Protein Desalting and Multiplexed, Label-Free Ligand Screening
PubMed - Native Flow-Induced Dispersion Analysis - Mass Spectrometry Enables Automated, Multiplexed Ligand Screening from Conventional, Nonvolatile Buffers
PubMed - Identification and characterization of tertiary lymphoid structures in brain metastases
PubMed - Determination of Minimum Surgical Caseloads for Major Oncologic Resections Using a Population-Attributable Fraction Model of Observational Data in Germany
PubMed - ErbB2/HER2-targeted CAR-NK cells eliminate breast cancer cells in an organoid model that recapitulates tumor progression
PubMed - ACO/ARO/AIO-22 - External beam radiotherapy combined with endorectal high-dose-rate brachytherapy in elderly and frail patients with rectal cancer: A prospective multicentre trial of the German Rectal Cancer Study Group
PubMed - Premature skeletal muscle aging in VPS13A deficiency relates to impaired autophagy
PubMed - Molecular signatures define BAP1-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes
PubMed - Endorectal brachytherapy for organ preservation in patients with rectal cancer: A paradigm shift?
PubMed - Optimized Long-TE 1H sLASER MR Spectroscopic Imaging at 3T for Separate Quantification of Glutamate and Glutamine in Glioma
PubMed - Inflammatory signaling pathways play a role in SYK inhibitor resistant AML
PubMed - Epidemiology and outcomes of Candida spp. bloodstream infections in cancer patients: a comparative retrospective study from a German tertiary cancer center
PubMed - Migration Dynamics of Human NK Cell Preparations in Microchannels and Their Invasion Into Patient-Derived Tissue
PubMed - Neoadjuvant chemoradiation for patients with resectable locally advanced oral cavity squamous cell carcinoma: Results of the prospective INVERT clinical trial
PubMed - Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans
PubMed - Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors
PubMed - AMP-activated protein kinase mediates adaptation of glioblastoma cells to conditions of the tumor microenvironment
PubMed - CAR-NK cell therapy combined with checkpoint inhibition induces an NKT cell response in glioblastoma
PubMed - The role of type I interferon signaling in myeloid anti-tumor immunity
PubMed - Frosted DNA: β-Galactosidase Control of Oligonucleotide Activity
PubMed - Chemotherapy before or after preoperative chemoradiotherapy and surgery for locally advanced rectal cancer: 5-year results of the CAO/ARO/AIO-12 trial - a general pairwise comparison
PubMed - Continuous map of early hematopoietic stem cell differentiation across human lifetime
PubMed - Radiation therapy in anal high-grade squamous intraepithelial lesions-a pattern of care analysis in German-speaking countries
PubMed - Single-stage versus two-stage resection for large anterior midline skull base meningiomas with bihemispheric peritumoral edema
PubMed - Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status
PubMed - IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis
PubMed - Advantages of 3D printed patient-individual moulds in brachytherapy for facial skin cancer
PubMed - Plasma lipidomic and metabolomic profiles in high-grade glioma patients before and after 72-h presurgery water-only fasting
PubMed - Corrigendum to "mFOLFOX6 versus mFOLFOX6 + aflibercept as neoadjuvant treatment in MRI-defined T3-rectal cancer: a randomized phase-II-trial of the German Rectal Cancer Study Group (CAO/ARO/AIO 0214) and the ABCSG (R-06)": [ESMO Open 9 (2024) 103703]
PubMed - CAR-CIK vs. CAR-T: benchmarking novel cytokine-induced killer cells as solid tumor immunotherapy in ErbB2+ rhabdomyosarcoma
PubMed - LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure
PubMed - Empowering Natural Killer Cells to Combat Acute Myeloid Leukemia: Perspective on CAR-NK Cell Therapy
PubMed - Enhanced conversion of T cells into CAR T cells by modulation of the MAPK/ERK pathway
PubMed - Efficacy and safety of immune checkpoint inhibition combined with concurrent chemoradiotherapy in patients with stage III unresectable non-small cell lung cancer: A systematic review and meta-analysis
PubMed - Application-driven validation of posteriors in inverse problems
PubMed - Survival among patients treated with total mesorectal excision or selective watch-and-wait after total neoadjuvant therapy: a pooled analysis of the CAO/ARO/AIO-12 and OPRA randomized phase II trials
PubMed - BRAT1 - a new therapeutic target for glioblastoma
PubMed - Impact of inhibitory KIR ligand mismatch and other variables on outcomes following myeloablative posttransplant cyclophosphamide-based T-cell-replete haploidentical bone marrow transplantation
PubMed - Expression of claudin-18.2 in cholangiocarcinoma: a comprehensive immunohistochemical analysis from a German tertiary centre
PubMed - Towards interactive AI-authoring with prototypical few-shot classifiers in histopathology
PubMed - Author Correction: Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
PubMed - DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma
PubMed - Impaired SARS-CoV-2-Specific CD8+ T Cells After Infection or Vaccination but Robust Hybrid T Cell Immunity in Patients with Multiple Myeloma
PubMed - EANO guideline on molecular testing of meningiomas for targeted therapy selection
PubMed - Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients
PubMed - An AMP-activated protein kinase-PGC-1α axis mediates metabolic plasticity in glioblastoma
PubMed - Establishment of Patient-Derived Organoids from Colorectal Cancer Resection Samples
PubMed - Tumor Response and Its Impact on Treatment Failure in Rectal Cancer: Does Intensity of Neoadjuvant Treatment Matter?
PubMed - Mapping Natural Sugars Metabolism in Acute Myeloid Leukaemia Using 2D Nuclear Magnetic Resonance Spectroscopy
PubMed - Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies
PubMed - A fast protocol for multicenter and multiparametric quantitative MRI studies in brain tumor patients using vendor sequences
PubMed - Gut microbial carcinogen metabolism: another avenue to cancer
PubMed - Pathological tissue changes in brain tumors affect the pH-sensitivity of the T1-corrected apparent exchange dependent relaxation (AREX) of the amide protons
PubMed - Phosphoproteomic Analysis of Signaling Pathways in Lymphomas
PubMed - Updated EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection-Update 1
PubMed - Transglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway
PubMed - Integrated multi-omics analysis of PBX1 in mouse adult neural stem- and progenitor cells identifies a transcriptional module that functionally links PBX1 to TCF3/4
PubMed - Inflammation in a ferroptotic environment
PubMed - EZB-type diffuse large B-cell lymphoma cell lines have superior migration capabilities compared to MCD-type
PubMed - CRISPR/Cas9 editing of NKG2A improves the efficacy of primary CD33-directed chimeric antigen receptor natural killer cells
PubMed - CD16+ as predictive marker for early relapse in aggressive B-NHL/DLBCL patients
PubMed - The Autophagy Receptor SQSTM1/p62 Is a Restriction Factor of HCMV Infection
PubMed - Dual Centrifugation-Based Screening for pH-Responsive Liposomes
PubMed - Irradiation alters extracellular vesicle microRNA load in the serum of patients with leukaemia
PubMed - Chem-CRISPR/dCas9FCPF: a platform for chemically induced epigenome editing
PubMed - A data-driven algorithm to determine 1H-MRS basis set composition
PubMed - In vivo CAR T cell therapy against angioimmunoblastic T cell lymphoma
PubMed - RUNX1 interacts with lncRNA SMANTIS to regulate monocytic cell functions
PubMed - Bispecific killer cell engagers employing species cross-reactive NKG2D binders redirect human and murine lymphocytes to ErbB2/HER2-positive malignancies
PubMed - Persistent Lymph Node Metastases After Neoadjuvant Chemoradiotherapy for Rectal Cancer
PubMed - mFOLFOX6 versus mFOLFOX6 + aflibercept as neoadjuvant treatment in MRI-defined T3-rectal cancer: a randomized phase-II-trial of the German Rectal Cancer Study Group (CAO/ARO/AIO 0214)
PubMed - Integrated analyses reveal two molecularly and clinically distinct subtypes of H3 K27M-mutant diffuse midline gliomas with prognostic significance
PubMed - Imperative role of adaptor proteins in macrophage toll-like receptor signaling pathways
PubMed - Interventional antibiotic treatment replacing antibiotic prophylaxis during allogeneic hematopoietic stem cell transplantation is safe and leads to a reduction of antibiotic administration
PubMed - Editorial: Women in cancer immunity and immunotherapy
PubMed - Cell blebbing novel therapeutic possibilities to counter metastasis
PubMed - Neutralizing IL-38 activates γδ T cell-dependent antitumor immunity and sensitizes for chemotherapy
PubMed - Amino acid metabolism in glioma: in vivo MR-spectroscopic detection of alanine as a potential biomarker of poor survival in glioma patients
PubMed - Superoxide dismutase 1 mediates adaptation to the tumor microenvironment of glioma cells via mammalian target of rapamycin complex 1
PubMed - Survival probability of epigenetically defined IDH-wild-type glioblastoma without necrosis or vascular proliferation
PubMed - Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for locally advanced rectal cancer: Pooled analysis of the CAO/ARO/AIO-12 and the OPRA randomized phase 2 trials
PubMed - Epigenetic profiling of prostate cancer reveals potential prognostic signatures
PubMed - T cell receptor-directed antibody-drug conjugates for the treatment of T cell-derived cancers
PubMed - Immune profiling and functional analysis of NK and T cells in ataxia telangiectasia
PubMed - Diagnosis of Hirschsprung disease by analyzing acetylcholinesterase staining using artificial intelligence
PubMed - T-cell specific in vivo gene delivery with DART-AAVs targeted to CD8
PubMed - Cranioencephalic functional lymphoid units in glioblastoma
PubMed - Corrigendum: Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells
PubMed - Small duct and large duct type intrahepatic cholangiocarcinoma reveal distinct patterns of immune signatures
PubMed - Identification of a putative molecular subtype of adult-type diffuse astrocytoma with recurrent MAPK pathway alterations
PubMed - Targeting the Sodium-Potassium Pump as a Therapeutic Strategy in Acute Myeloid Leukemia
PubMed - Real-world effectiveness of first-line azacitidine or decitabine with or without venetoclax in acute myeloid leukemia patients unfit for intensive therapy
PubMed - Systemic Treatment of Recurrent Hepatocellular Carcinoma after Liver Transplantation: A Multicenter Trial
PubMed - (Auto)immunity in focal epilepsy: mechanisms of (auto‑)immune-inflammatory epileptogenic neurodegeneration
PubMed - ZEB1-mediated fibroblast polarization controls inflammation and sensitivity to immunotherapy in colorectal cancer
PubMed - A Mouse Model of X-Linked Chronic Granulomatous Disease for the Development of CRISPR/Cas9 Gene Therapy
PubMed