2024-03-22
New Research Results – Safety of Short-Term Cultivated CAR T Cells in Cancer Immunotherapy
To the articleEvents and Media
Press Releases
2024-02-01
The German Science and Humanities Council (Wissenschaftsrat) attests the Georg-Speyer-Haus “Impressive contributions to tumor research”
To the article2024-01-02
Katharina Imkeller appointed Professor for Translational Neurooncology and Quantitative Immunology at LOEWE-Zentrum Frankfurt Cancer Institute
To the articlePublications
- Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
PubMed - Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)
PubMed - EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
PubMed - Phosphatidylserine externalization as immune checkpoint in cancer
PubMed - Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study
PubMed - Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models
PubMed - Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche
PubMed - Feasibility of Next-generation Sequencing of Liquid Biopsy (Circulating Tumor DNA) Samples and Tumor Tissue from Patients with Metastatic Prostate Cancer in a Real-world Clinical Setting in Germany
PubMed - Future direction of total neoadjuvant therapy for locally advanced rectal cancer
PubMed - Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look
PubMed - Evolutionary trajectories of small cell lung cancer under therapy
PubMed - Fluorescence confocal microscopy-complete digitization of pathology
PubMed - A guideline on the molecular ecosystem regulating ferroptosis
PubMed - Deep-learning-based reconstruction of undersampled MRI to reduce scan times: a multicentre, retrospective, cohort study
PubMed - Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors
PubMed - PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle
PubMed - CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation
PubMed - Digital Pathology
PubMed - Heterogeneity of small duct- and large duct-type intrahepatic cholangiocarcinoma
PubMed - miR-147b mediated suppression of DUSP8 promotes lung cancer progression
PubMed - PC4: A new regulator of cyclin D1 transcript levels
PubMed - Prevalence of TERT Promoter Mutations in Orbital Solitary Fibrous Tumors
PubMed - Tumor associated macrophages transfer ceruloplasmin mRNA to fibrosarcoma cells and protect them from ferroptosis
PubMed - Challenges of automation in quantitative evaluation of liver biopsies : Automatic quantification of liver steatosis
PubMed - The model transferability of AI in digital pathology : Potential and reality
PubMed - Downregulation of V-ATPase V0 Sector Induces Microvillus Atrophy Independently of Apical Trafficking in the Mammalian Intestine
PubMed - Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch
PubMed - Smart Conditioning with Venetoclax-Enhanced Sequential FLAMSA + RIC in Patients with High-Risk Myeloid Malignancies
PubMed - Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells
PubMed - Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma
PubMed - Patient-reported outcomes in advanced NSCLC before and during the COVID-19 pandemic: Real-world data from the German prospective CRISP Registry (AIO-TRK-0315)
PubMed - Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines
PubMed - The neuronal transcription factor MEIS2 is a calpain-2 protease target
PubMed - Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors
PubMed - Histomolecular classification of urothelial carcinoma of the urinary bladder : From histological phenotype to genotype and back
PubMed - Cytokine-induced killer (CIK) cells, successes and challenges: report on the first international conference dedicated to the clinical translation of this unique adoptive cell immunotherapy
PubMed - Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas
PubMed - Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
PubMed - Molecular Marvels: Small Molecules Paving the Way for Enhanced Gene Therapy
PubMed - Manufacturing of primary CAR-NK cells in an automated system for the treatment of acute myeloid leukemia
PubMed - Response to Bruton's tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
PubMed - Morphology-based molecular classification of spinal cord ependymomas using deep neural networks
PubMed - Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3
PubMed - Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death
PubMed - Tumor-host cell interaction in the microenvironment: new target points for treatment?
PubMed - Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis
PubMed - Molecular refinement of pilocytic astrocytoma in adult patients
PubMed - Heterogeneity of tertiary lymphoid structures in cancer
PubMed - Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3
PubMed - The impact of referring patients with drug-resistant focal epilepsy to an epilepsy center for presurgical diagnosis
PubMed - Multimodal analysis methods in predictive biomedicine
PubMed - Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation
PubMed - The MYC-Regulated RNA-Binding Proteins hnRNPC and LARP1 Are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival
PubMed - Wnt/β-Catenin-Signaling Modulates Megakaryopoiesis at the Megakaryocyte-Erythrocyte Progenitor Stage in the Hematopoietic System
PubMed - Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients
PubMed - Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
PubMed - Treatment of very elderly glioblastoma patients ≥ 75 years of age: whom to treat
PubMed - Gliomatosis cerebri (GC) growth pattern: A single-center analysis of clinical, histological, and molecular characteristics of GC and non-GC glioblastoma
PubMed - DistSNE: Distributed computing and online visualization of DNA methylation-based central nervous system tumor classification
PubMed - A new age of precision gene therapy
PubMed - Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression
PubMed - AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery
PubMed - Impact of consensus molecular subtypes on survival with and without adjuvant chemotherapy in muscle-invasive urothelial bladder cancer
PubMed - Trends and Differences in Status Epilepticus Treatment of Children and Adults Over 10 Years: A Comparative Study of Medical Records (2012-2021) from a University Hospital in Germany
PubMed - Dataset of single nucleotide polymorphisms of immune-associated genes in patients with SARS-CoV-2 infection
PubMed - PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia
PubMed - The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males
PubMed - SH2 domain-containing inositol 5-phosphatases support the survival of Burkitt lymphoma cells by promoting energy metabolism
PubMed - CAR Gene Delivery by T-cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms
PubMed - Overall Survival After Treatment Failure Among Patients With Rectal Cancer
PubMed - The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
PubMed - Early Efficacy End Points in Neoadjuvant Rectal Cancer Trials: Surrogacy Revisited
PubMed - Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer
PubMed - Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units
PubMed - Prevalence and implications of significance testing for baseline covariate imbalance in randomised cancer clinical trials: The Table 1 Fallacy
PubMed - Mean global DNA methylation serves as independent prognostic marker in IDH-wildtype glioblastoma
PubMed - Corrigendum to "Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes" [European Urology Oncology (2023)]
PubMed - Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapy
PubMed - Distinct and targetable role of calcium-sensing receptor in leukaemia
PubMed - Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α
PubMed - Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15
PubMed - A Novel Type of IDH-wildtype Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile
PubMed - Efficacy and safety of bemcentinib in patients with advanced myelodysplastic neoplasms or acute myeloid leukemia failing hypomethylating agents- the EMSCO phase II BERGAMO trial
PubMed - The multiple functions of miR-574-5p in the neuroblastoma tumor microenvironment
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PubMed - Double trouble: IRAK1/4 inhibitors in AML/MDS
PubMed - Machine-Learning-Aided Prediction of Brain Metastases Development in Non-Small-Cell Lung Cancers
PubMed - Active Autophagy Is Associated with Favorable Outcome in Patients with Surgically Resected Cholangiocarcinoma
PubMed - Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD2-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2
PubMed - Editorial: Translating NK cell scientific research to clinical product manufacturing
PubMed - ErbB2 (HER2)-CAR-NK-92 cells for enhanced immunotherapy of metastatic fusion-driven alveolar rhabdomyosarcoma
PubMed - Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma
PubMed - Case Report: Durable therapy response to Osimertinib in rare EGFR Exon 18 mutated NSCLC
PubMed - Formate promotes invasion and metastasis in reliance on lipid metabolism
PubMed - CD62L as target receptor for specific gene delivery into less differentiated human T lymphocytes
PubMed - Disease-free survival as the endpoint in multimodal rectal cancer trials: have we got this right?
PubMed - The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
PubMed - Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability
PubMed - Ovarian cancer: molecular pathology and molecularly targeted therapy
PubMed - Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes
PubMed