KARRIERE

Wir sind immer auf der Suche nach motivierten Menschen mit Leidenschaft für die translationale Krebsforschung, die unser Team verstärken möchten.

Schauen Sie sich die offenen Stellen an oder senden Sie uns Ihre Initiativbewerbung mit der Angabe, an welchen Gruppen Sie interessiert sind.

OPEN POSITIONS

PhD Position - Exploiting 3D organotypic niche models to dissect the cellular crosstalk between niche and haematopoietic stem cell/progenitors (HSPCs) in human myelodysplastic syndromes (MDS).

The PhD candidate will combine experimental and computational approaches to dissect the cellular crosstalk between niche and haematopoietic stem/progenitor cells (HSPCs) in myelodysplastic syndromes (MDS) with the goal to identify niche dependencies that can be exploited for disease interception. The project will make extensive use of innovative 3D Human Organotypic Marrow Environments (3DHOMEs) to functionally evaluate niche dependencies and perform screens to identify druggable modules that promote the fitness and progressive clonal dominance of malignant MDS cells. Results will be confirmed using patient-derived xenograft models and primary patient samples.

To achieve this the successful candidate will use a large panel of wet lab techniques, including primary cell culture, multiparameter flow cytometry, various imaging platforms, CRISPR/Cas9 mediated genetic engineering and animal work. Additionally, the candidate will use single cell RNA sequencing approaches, to carry out a comprehensive and spatially resolved analysis of the composition and priming of both the MDS and the stromal compartment. As such, preference will be given to candidate(s) with experience/background in computational science/bioinformatics.

Supervisor: Hind Medyouf (visit website here).

Envisioned secondments: To further broaden the expertise of the PhD candidate and support the project, two secondments of 3 months at GenomeScan B.V. (Leiden, The Netherlands) and 2 months at University of Bergen (Bergen, Norway), will be offered as an integral part of the PhD project.

Application deadline: 30 June 2021 (midnight CEST). Applications will be solely accepted through the INTERCEPT-MDS online application form and must be in English.


application

Postdoc or PhD student - Clinical Translation Program Brain Cancer

CAREER CONTACT

Bitte senden Sie Ihren Lebenslauf, Motivationsschreiben sowie Kontaktdaten von drei Referenzen als eine pdf Datei an:

PROF. DR. FLORIAN GRETEN
Sprecher des FCI

career@fci.health 

oder nutzen Sie unser Bewerbungsformular:

  • Akzeptierte Datentypen: pdf.
    Bitte senden Sie Ihren Lebenslauf, Motivationsschreiben sowie Kontaktdaten von drei Referenzen als eine pdf Datei (max. 20 MB).