The position is offered at the Institute of Neuroradiology (Prof. Dr. Elke Hattingen, Dr. Ulrich Pilatus) together with the Mildred Scheel Career Center (MSNZ) Frankfurt . Research projects will be conducted primarily at the close-by Brain lmaging Center (BIC), a collaborative research center cre-ated by the Goethe-University Frankfurt, the Ernst-Strüngmann Institute and the Max-Planck-Institute.

The Institute of Neuroradiology specializes in advanced MR imaging methods to evaluate different biological features related to diagnosis and targeted treatment. While focusing on patients with brain tumors also neurological disorders are studied.

One important current project aims at adding 1H / 31P – MRS in vivo metabolic profiling as a novel molecular level to the multi-omics assessment of lymphoma (superficial lymph nodes) to identify disease subtypes and predictive biomarkers. The successful candidate should participate in this project by implementation and optimization of the required MRS sequences. We are looking for someone dedicated to establishing project specific MRS (and CEST) methods as well as standardized post-processing and data quantification.

We expect

• University degree in medicine or life science or physics and PhD or MD or MD-PhD with outstanding scientific credentials and postdoc experience
• publications in high-ranking international scientific journals
• expertise in cancer research and/or MR (especially MRS) imaging technologies
• a competitive research proposal within the outlined project
• strong interest in promoting your scientific qualifications and developing into an independent group leader
• broad experience in the management of scientific projects
• high level of motivation and communication skills

We offer

• development of a personal scientific profile with the help of an internal mentor
• integration into the FCI, the University Cancer Center (UCT) Frankfurt-Marburg and the DKTK
• access to scientific infrastructure including two state-of-the-art 3T MR scanners with an advanced multi-nuclear Spectroscopy application dedicated for research only at the BIC and in the near future to an additional 7T MRI scanner at the new site of the BIC (Co-BIC)
• support by the methodological research group “MR Core Structure” at the BIC that promotes the creation of novel data acquisition and analysis techniques
• excellent basic research closely linked to translational and clinical aspects in close cooperation with clinical sci-entists
• opportunity for a research stay at a national or international research institution
• participation in further training and qualification programs of the MSNZ such as personal soft skills and career development

We are looking forward to your application!

More Information on the position and how to apply can be found here!

We are currently seeking a motivated PhD Student for the Research Group of Computational Immunology, a newly established group led by Dr. Katharina Imkeller within the Edinger Institute (Director: Prof. Dr. Karl H. Plate) at the University Hospital Frankfurt and the Mildred Scheel Career Center (MSNZ) Frankfurt, an excellence program supporting careers in translational cancer research (funded by the German Cancer Aid).

Your role

The planned PhD project focuses on the development of models to study immune responses in patient undergoing immunotherapy and to identify biomarkers that predict resistance to therapy. The research project covers method development and analysis of different types of multi-omics data (single-cell sequencing, proteomics, multiplexed immunofluoresence images) and adaptive immune receptor sequences (B cell and T cell receptors).

Who you are

• You have a master’s degree in computational biology, bioinformatics, biophysics or related field (or a degree biology/medicine with excellent mathematics and
programming skills)
• You have hands-on experience in programming and data analysis (Python or R)
• You have strong interest in immunology or cancer biology
• Ability to conduct independent research and motivation to join an international and interdisciplinary research team
• Fluency in English language

For more information please check:

https://agimkeller.github.io/recruiting/

Applications must by submitted here:

https://www.kgu.de/index.php?id=12055

A Post-Doctoral position (TV-H E13) and a PhD position (TV-H E13, 65%) are available in the group of Florian Greten at the Georg-Speyer-Haus – Institute for Tumor Biology and Experimental Therapy in Frankfurt am Main.

Positions are available immediately.

• We are looking for highly motivated candidates with an excellent track record and a strong  interest in pursuing an academic career to participate in projects funded by an ERC Advanced Grant on Cell Plasticity in Metastatic Colorectal Cancer (PLASTICAN).
• We will perform well-defined hypothesis driven approaches to characterize the plasticity of both tumor and stromal cells and to develop innovative tools that will allow the functional analysis of distinct cell types in the stroma of primary tumors as well as in the pre-metastatic niche in the liver.
• Candidate for these positions should have a strong background in tumor biology and immunology and should have experience with mouse models.

As part of the work-life balance, we offer you a great variety of opportunities, such as flexible working hours and help with balancing your career and family. We offer an interesting and highly autonomous field of responsibilities. You will work closely with our team of researchers. The salary is according to TV-H with all social benefits of the public service. The position is initially limited for 2 years. An extension is planned. Applications from women are explicitly welcome. Handicapped persons will be preferred in case of equal qualification. The position can be split and applications for part-time work are welcome.

Please send your application as a single PDF containing a cover letter, a CV and two letters of recommendation to:

Bewerbung@georg-speyer-haus.de

Georg-Speyer-Haus

Human Resources

Paul-Ehrlich-Str. 42-44

60596 Frankfurt am Main

The Georg-Speyer-Haus – Institute for Tumor Biology and Experimental Therapy in Frankfurt am Main is an academic non-profit research institute supported by the Federal Ministry of Health and the Ministry for Sciences and Arts of the State of Hessen. The institute is dedicated to basic and translational cancer research in the context of the tumor microenvironment and closely cooperates with the Goethe University Frankfurt and the Frankfurt University Hospital. It provides access to a broad variety of core facilities and an excellent scientific environment. Its international working environment promotes equal opportunities for men and women, regardless of their nationality, age, race, religion and beliefs, disability and sexual orientation, under criteria of scientific excellence.