2025-11-10
Land fördert das LOEWE-Zentrum „Frankfurt Cancer Institute“ weiter
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Publications
- Distinct Molecular Pathways Driving Thymic and Pulmonary Neuroendocrine Neoplasms: Organ of Origin Defines Molecular Identity and Yields CD44 as a Marker of Pulmonary Neuroendocrine Tumors
PubMed - DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells
PubMed - Visual extraction of individual patient data from published kaplan-meier survival plots using a web-based application offering different reconstruction methods (V-Exploder)
PubMed - Dual-Foundation-Model Ensemble Predicts Gene Expression in Muscle-Invasive Bladder Cancer for Patient Outcome Stratification
PubMed - Real-World First-Line Treatment Characteristics and Physician Drivers in Advanced/Metastatic Non-Small Cell Lung Cancer, PD-L1 ≥ 50%, and without Actionable Genomic Alterations
PubMed - Lung cancer after allogeneic hematopoietic stem cell transplantation
PubMed - The protein kinase IKK epsilon shapes the melanoma tumor microenvironment by modulating angiogenesis and the T-cell immunity
PubMed - Frameless VarioGuide biopsy for pediatric brainstem lesions in the molecular era: diagnostic performance and workflow characteristics in a comparative single-center series
PubMed - Modulating pseudokinase conformation from the ATP-binding site
PubMed - Decreased FSP1 expression under chronic hypoxia sensitizes human macrophages towards ferroptosis
PubMed - Age-associated loss of lymphatic vessels promotes cardiac inflammation
PubMed - Pitfalls in 2HG Detection With TE-Optimized MRS at 3T
PubMed - Outcomes of elderly patients treated with chemoradiotherapy for anal squamous cell carcinoma: a multicenter study of the German cancer consortium - radiation oncology group (DKTK-ROG)
PubMed - Crosstalk Between mTOR and NF-κB Signaling Pathways in Clear Cell Renal Cell Carcinoma
PubMed - Image-guided high-dose-rate brachytherapy after short-course external beam radiotherapy for elderly/frail rectal cancer patients
PubMed - Trends in radiation oncology between 2015 and 2022: report from a German university radio-oncology department
PubMed - Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137
PubMed - High-content imaging workflow for single-cell drug response profiling of acute myeloid leukemia subtypes
PubMed - Sleep duration links to biological aging clocks: when sleep gets tough, aging gets going
PubMed - Isoform-Selective Targeting of Akt Through Covalent Allosteric Inhibition
PubMed - Accelerate Your Science: Direct-to-Biology Strategies in Medicinal Chemistry
PubMed - Age- and sex-dependent heterogeneity during LPS-induced murine acute lung injury
PubMed - Oncofetal cell states: cell plasticity drives invasion in premetastatic colorectal tumors
PubMed - Response to Trastuzumab Deruxtecan in a Patient With EGFR-Mutated NSCLC and Transformation to SCLC Harboring HER2 Amplification: A Case Report
PubMed - Anal High-Grade Squamous Intraepithelial Lesions in People Living with HIV: A Systematic Review of Treatment Outcomes
PubMed - Lomustine with or without procarbazine in recurrent glioblastoma-A propensity score matching analysis
PubMed - Benchmarking cell-type deconvolution in cross-platform transcriptomic data
PubMed - Sellar region neurocytomas exhibit a CIMP and neuroendocrine-like epigenetic signature distinct from other intra-axial neurocytomas
PubMed - Neurocognitive functioning in long-term survivors of glioblastoma, IDH-wildtype and astrocytoma, IDH-mutant, CNS WHO grade 4: A report from EORTC 1419 (ETERNITY)
PubMed - Total neoadjuvant therapy for rectal cancer: where are we now, where do we go?
PubMed - Intratumoral IDH1 mutation status in intrahepatic cholangiocarcinoma is homogeneous
PubMed - Reassessing the role of CEA in the treatment of rectal cancer in the era of TNT
PubMed - Robustness of radiomics-based machine learning to real-world MRI distribution shifts: a phantom study
PubMed - Efficacy of imatinib maintenance after stem cell transplantation for Ph+/BCR::ABL1 positive ALL: long-term outcome of a randomized trial and impact of peritransplant minimal residual disease
PubMed - Time-dependent prognostic value of automated Ki67 assessment and its integration with molecular risk profiling in WHO grade 2 meningioma
PubMed - Depletion of IL-10 in CAR-NK cells augments reprogramming of the tumor microenvironment and ameliorates therapeutic efficacy
PubMed - Durvalumab Consolidation After Definitive Chemoradiotherapy in Patients with Unresectable Stage III Non-Small Cell Lung Cancer: A Real-World Cohort Analysis from the German Prospective, Observational CRISP Registry (AIO-TRK-0315)
PubMed - Methylation profiling and alternative classification approaches in a glioma-enriched FFPE stereotaxic biopsy cohort
PubMed - Growing clinical evidence for successful in vivo generation of CAR T cells directed against hematologic malignancies
PubMed - Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting
PubMed - Riding toward Selectivity: Optimization of Covalent 7-Azaindole-Based BMX Kinase Inhibitors
PubMed - Endothelial cytochrome P450 -derived cholesterol limits angiogenesis
PubMed - The PRECISE European initiative for cancer-vulnerability mapping and prediction
PubMed - The European Association for Neuro-oncology (EANO) Consensus Statement on Radiation Necrosis
PubMed - AI-based selection of tumor regions for genomic profiling in neuropathology
PubMed - GM-CSF downregulates type I IFN responses in glioblastoma-associated monocytes
PubMed - Patient-derived resources for decoding and targeting brain metastases ecosystems
PubMed - An in vivo platform to jointly monitor cellular and metabolic responses to chemotherapy
PubMed - Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia
PubMed - Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity
PubMed - A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence
PubMed - Author Correction: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
PubMed - Interpretable multi-omics integration across mixed-order tensors with MANTRA
PubMed - Structure-Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile
PubMed - Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes
PubMed - Pathogenesis of diffuse large B cell lymphoma proteogenotypes
PubMed - RNA-based full length immunoglobulin light chain sequencing reveals lambda constant domain mutations with potential implications for thermodynamic stability in light chain amyloidosis
PubMed - Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States
PubMed - Primary mismatch repair deficient glioma, IDH-wildtype and H3-wildtype: A giant cell tumor with potential for long-term survival occurring at all ages
PubMed - Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer
PubMed - Necroptosis triggers inflammatory interferon signatures in patient-derived metastatic breast cancer organoids
PubMed - MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
PubMed - vanA-consistent phenotype vancomycin-resistant enterococcal colonization is associated with inferior overall survival in acute myeloid leukemia patients undergoing intensive chemotherapy: a single-center retrospective study
PubMed - Toward trustworthy healthcare AI: designing academic research for translation readiness
PubMed - Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity
PubMed - Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease
PubMed - CD155-CD96 keeps quiescent persister tumor cells in check
PubMed - Drugs that act on both G protein-coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy
PubMed - Prognostic value of DICER and CA9 expression in patients with anal squamous cell carcinoma treated with definitive chemoradiotherapy
PubMed - Emergency reversal of Rivaroxaban with Andexanet alfa in a child with hemorrhagic brain metastasis from Wilms tumor
PubMed - Fibroblast dynamics in colorectal cancer: stability, plasticity, and novel markers
PubMed - Loss of meningothelial identity and mesenchymal fate switching in NF2-mutant meningiomas
PubMed - Single cell transcriptional evolution of myeloid leukemia of Down syndrome
PubMed - Expression of cFLIP in B cells is essential for diffuse large B-cell lymphoma pathogenesis
PubMed - Stem11 score: toward rapid clinical prognostication for acute myeloid leukemia
PubMed - In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T
PubMed - Treatment Patterns, Outcome, and Quality of Life of Patients With Extensive-Stage SCLC Receiving Third-Line Therapy-Data From the German CRISP Registry (AIO-TRK-0315): A Brief Report
PubMed - Endogenous protein tagging coupled with a CRISPR screening approach identifies UBE3C as a potential MYC oncogene regulator
PubMed - Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor
PubMed - Nuclear transcriptional condensates as drivers and therapeutic targets in NPM1-mutated AML
PubMed - Targeting glioblastoma mitochondrial metabolism with S-Gboxin induces cytotoxicity under conditions of the tumor microenvironment
PubMed - Tumor-associated epilepsy and high expression of xCT shape the proteome of IDH-wildtype glioblastoma
PubMed - Prediction of the individual risk for the development of brain metastases in patients with non-oncogene-addicted non-small cell lung cancer: Real-world data from the German prospective CRISP registry (AIO-TRK-0315)
PubMed - Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer
PubMed - Analysis of structure and conservation for supporting functional evaluation of PMS2 missense variants
PubMed - Regulation of the immune CD155-CD226-TIGIT axis by cyclin D-CDK4/6
PubMed - Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML
PubMed - An international multi-centre study to develop and validate federated learning-based prognostic models for anal cancer
PubMed - Fast and accessible morphology-free functional fluorescence imaging analysis
PubMed - Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease
PubMed - Ligand-based CAR design enhances durability of CD70-targeted CAR T cells in glioblastoma
PubMed - Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment
PubMed - Genetic interactions, synthetic lethality and complexity in cancer vulnerability mapping-Insights and perspectives from the 2nd EuroDepMap symposium
PubMed - Clinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis
PubMed - Co-administered internalizing RGD peptide boosts anti-PD-L1 therapy in hepatocellular carcinoma
PubMed - Oxaliplatin-induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose-response relationship and impact on quality of life
PubMed - Feasibility and safety of nintedanib in combination with nivolumab in pretreated patients with advanced or metastatic adenocarcinoma of the lung - An AIO phase Ib/II trial
PubMed - Institutional variability in testing for actionable genetic alterations in patients with stage IIIB/C or IV non-small cell lung cancer: A real-world study from the German prospective, observational, multicenter CRISP registry (AIO-TRK-0315)
PubMed - RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma
PubMed - Axes of biological variation in diffuse large B cell lymphoma
PubMed