Events und Presse

Events

Tumor-associated neutrophils in non-small cell lung cancer

29-05-2024 - 29-05-2024
14:30 - 15:30
Etienne Meylan, Lung Cancer & Immuno-Oncology Laboratory, Université Libre de Bruxelles
Florian Greten
Georg-Speyer-Haus, Lecture hall, ground floor
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The dynamics of WNT-mediated cell differentiation in intestinal organoids

19-06-2024
10:00 - 11:00
Sander Tans, AMOLF Amsterdam Delft University of Technology
Henner Farin
Georg-Speyer-Haus, Lecture hall, ground floor
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Pinpointing the role of CCR7+ dendritic cells within tumor microenvironment

04-07-2024
14:00 - 15:00
Mauro Di Pilato , Department of Immunology UT MD Anderson Cancer Center Houston, Texas
Florian Greten
Georg-Speyer-Haus, Lecture hall, ground floor
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3rd Frankfurt Cancer Conference 2024 „Targeting the tumor-host interface“.

28-08-2024 - 30-08-2024
Various
Campus Westend, Auditorium Complex, Goethe University, Frankfurt am Main, Germany
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5th Rhein-Main Cancer Retreat

07-11-2024 - 08-11-2024
9:00 - 18:00
Various,
DKTK / LOEWE-FCI / MSNZ
Collegium Glashütten
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Symposium – the tumor microenvironment in breast cancer and precision medicine

03-12-2024 - 04-12-2024
9:00 - 17:00
Various, various
Zuzana Tatarova
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Pressemeldungen

2024-03-22

Neue Forschungsergebnisse – Sicherheit von kurzzeitig kultivierten CAR-T-Zellen in der Krebsimmuntherapie

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2024-03-07

Wirkstoffentwicklung: Deutsche Krebshilfe fördert zwei Projekte an Goethe-Universität und Universitätsklinikum mit Beteiligung von FCI-Mitgliedern

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2024-02-01

Wissenschaftsrat bescheinigt dem Georg-Speyer-Haus „Beeindruckende Beiträge zur Tumorforschung“

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Publications

  • Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors
    PubMed
  • Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
    PubMed
  • 2D 1H sLASER Long-TE and 3D 31P Chemical Shift Imaging at 3 T for Monitoring Fasting-Induced Changes in Brain Tumor Tissue
    PubMed
  • Bortezomib promotes the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/Her2-targeted CAR-NK-92 cells via DR5 upregulation
    PubMed
  • Molecular targets of glucocorticoids that elucidate their therapeutic efficacy in aggressive lymphomas
    PubMed
  • Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial
    PubMed
  • Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma
    PubMed
  • Nanopore sequencing from formalin-fixed paraffin-embedded specimens for copy-number profiling and methylation-based CNS tumor classification
    PubMed
  • Murine Alox8 versus the human ALOX15B ortholog: differences and similarities
    PubMed
  • Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells
    PubMed
  • Influenza A virus replicates productively in primary human kidney cells and induces factors and mechanisms related to regulated cell death and renal pathology observed in virus-infected patients
    PubMed
  • Checkpoint Inhibitor Monotherapy in Potentially Trial-Eligible or Trial-Ineligible Patients With Metastatic NSCLC in the German Prospective CRISP Registry Real-World Cohort (AIO-TRK-0315)
    PubMed
  • EpiDiP/NanoDiP: a versatile unsupervised machine learning edge computing platform for epigenomic tumour diagnostics
    PubMed
  • Phosphatidylserine externalization as immune checkpoint in cancer
    PubMed
  • Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study
    PubMed
  • Early induction of cytokine release syndrome by rapidly generated CAR T cells in preclinical models
    PubMed
  • Clonal hematopoiesis and its impact on the aging osteo-hematopoietic niche
    PubMed
  • Feasibility of Next-generation Sequencing of Liquid Biopsy (Circulating Tumor DNA) Samples and Tumor Tissue from Patients with Metastatic Prostate Cancer in a Real-world Clinical Setting in Germany
    PubMed
  • Future direction of total neoadjuvant therapy for locally advanced rectal cancer
    PubMed
  • Adaptor molecules mediate negative regulation of macrophage inflammatory pathways: a closer look
    PubMed
  • Evolutionary trajectories of small cell lung cancer under therapy
    PubMed
  • Fluorescence confocal microscopy-complete digitization of pathology
    PubMed
  • A guideline on the molecular ecosystem regulating ferroptosis
    PubMed
  • Deep-learning-based reconstruction of undersampled MRI to reduce scan times: a multicentre, retrospective, cohort study
    PubMed
  • Development of Selective Pyrido[2,3-d]pyrimidin-7(8H)-one-Based Mammalian STE20-Like (MST3/4) Kinase Inhibitors
    PubMed
  • PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle
    PubMed
  • CAR-mediated targeting of NK cells overcomes tumor immune escape caused by ICAM-1 downregulation
    PubMed
  • Digital Pathology
    PubMed
  • Heterogeneity of small duct- and large duct-type intrahepatic cholangiocarcinoma
    PubMed
  • miR-147b mediated suppression of DUSP8 promotes lung cancer progression
    PubMed
  • PC4: A new regulator of cyclin D1 transcript levels
    PubMed
  • Prevalence of TERT Promoter Mutations in Orbital Solitary Fibrous Tumors
    PubMed
  • Tumor associated macrophages transfer ceruloplasmin mRNA to fibrosarcoma cells and protect them from ferroptosis
    PubMed
  • Challenges of automation in quantitative evaluation of liver biopsies : Automatic quantification of liver steatosis
    PubMed
  • The model transferability of AI in digital pathology : Potential and reality
    PubMed
  • Downregulation of V-ATPase V0 Sector Induces Microvillus Atrophy Independently of Apical Trafficking in the Mammalian Intestine
    PubMed
  • Discovery of a Small Molecule Activator of Slack (Kcnt1) Potassium Channels That Significantly Reduces Scratching in Mouse Models of Histamine-Independent and Chronic Itch
    PubMed
  • Smart Conditioning with Venetoclax-Enhanced Sequential FLAMSA + RIC in Patients with High-Risk Myeloid Malignancies
    PubMed
  • Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells
    PubMed
  • Intrathecal IgM synthesis as a diagnostic marker in patients with suspected CNS lymphoma
    PubMed
  • Patient-reported outcomes in advanced NSCLC before and during the COVID-19 pandemic: Real-world data from the German prospective CRISP Registry (AIO-TRK-0315)
    PubMed
  • Synthesis and biological evaluation of 1H-pyrrolo[3,2-g]isoquinolines
    PubMed
  • The neuronal transcription factor MEIS2 is a calpain-2 protease target
    PubMed
  • Actinin-4 controls survival signaling in B cells by limiting the lateral mobility of B-cell antigen receptors
    PubMed
  • Histomolecular classification of urothelial carcinoma of the urinary bladder : From histological phenotype to genotype and back
    PubMed
  • Cytokine-induced killer (CIK) cells, successes and challenges: report on the first international conference dedicated to the clinical translation of this unique adoptive cell immunotherapy
    PubMed
  • Molecular characteristics and improved survival prediction in a cohort of 2023 ependymomas
    PubMed
  • Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation
    PubMed
  • Molecular Marvels: Small Molecules Paving the Way for Enhanced Gene Therapy
    PubMed
  • Manufacturing of primary CAR-NK cells in an automated system for the treatment of acute myeloid leukemia
    PubMed
  • Response to Bruton's tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
    PubMed
  • Morphology-based molecular classification of spinal cord ependymomas using deep neural networks
    PubMed
  • Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3
    PubMed
  • Mammalian target of rapamycin inhibition protects glioma cells from temozolomide-induced cell death
    PubMed
  • Tumor-host cell interaction in the microenvironment: new target points for treatment?
    PubMed
  • Interferon regulatory factor 4 plays a pivotal role in the development of aGVHD-associated colitis
    PubMed
  • Molecular refinement of pilocytic astrocytoma in adult patients
    PubMed
  • Heterogeneity of tertiary lymphoid structures in cancer
    PubMed
  • Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3
    PubMed
  • The impact of referring patients with drug-resistant focal epilepsy to an epilepsy center for presurgical diagnosis
    PubMed
  • Multimodal analysis methods in predictive biomedicine
    PubMed
  • Mmp12 Is Translationally Regulated in Macrophages during the Course of Inflammation
    PubMed
  • The MYC-Regulated RNA-Binding Proteins hnRNPC and LARP1 Are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival
    PubMed
  • Wnt/β-Catenin-Signaling Modulates Megakaryopoiesis at the Megakaryocyte-Erythrocyte Progenitor Stage in the Hematopoietic System
    PubMed
  • Cytokine-responsive T- and NK-cells portray SARS-CoV-2 vaccine-responders and infection in multiple myeloma patients
    PubMed
  • Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
    PubMed
  • Treatment of very elderly glioblastoma patients ≥ 75 years of age: whom to treat
    PubMed
  • Gliomatosis cerebri (GC) growth pattern: A single-center analysis of clinical, histological, and molecular characteristics of GC and non-GC glioblastoma
    PubMed
  • DistSNE: Distributed computing and online visualization of DNA methylation-based central nervous system tumor classification
    PubMed
  • A new age of precision gene therapy
    PubMed
  • Prostaglandin E2 Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression
    PubMed
  • AAV vectors displaying bispecific DARPins enable dual-control targeted gene delivery
    PubMed
  • Impact of consensus molecular subtypes on survival with and without adjuvant chemotherapy in muscle-invasive urothelial bladder cancer
    PubMed
  • Trends and Differences in Status Epilepticus Treatment of Children and Adults Over 10 Years: A Comparative Study of Medical Records (2012-2021) from a University Hospital in Germany
    PubMed
  • Dataset of single nucleotide polymorphisms of immune-associated genes in patients with SARS-CoV-2 infection
    PubMed
  • PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia
    PubMed
  • The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury in murine males
    PubMed
  • SH2 domain-containing inositol 5-phosphatases support the survival of Burkitt lymphoma cells by promoting energy metabolism
    PubMed
  • CAR Gene Delivery by T-cell Targeted Lentiviral Vectors is Enhanced by Rapamycin Induced Reduction of Antiviral Mechanisms
    PubMed
  • Overall Survival After Treatment Failure Among Patients With Rectal Cancer
    PubMed
  • The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
    PubMed
  • Early Efficacy End Points in Neoadjuvant Rectal Cancer Trials: Surrogacy Revisited
    PubMed
  • Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer
    PubMed
  • Short-term predictor for COVID-19 severity from a longitudinal multi-omics study for practical application in intensive care units
    PubMed
  • Prevalence and implications of significance testing for baseline covariate imbalance in randomised cancer clinical trials: The Table 1 Fallacy
    PubMed
  • Mean global DNA methylation serves as independent prognostic marker in IDH-wildtype glioblastoma
    PubMed
  • Corrigendum to "Proposal for a Novel Histological Scoring System as a Potential Grading Approach for Muscle-invasive Urothelial Bladder Cancer Correlating with Disease Aggressiveness and Patient Outcomes" [European Urology Oncology (2023)]
    PubMed
  • Epigenetic targeting to enhance acute myeloid leukemia-directed immunotherapy
    PubMed
  • Distinct and targetable role of calcium-sensing receptor in leukaemia
    PubMed
  • Fuzzy interactions between the auto-phosphorylated C-terminus and the kinase domain of CK1δ inhibits activation of TAp63α
    PubMed
  • Myeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15
    PubMed
  • A Novel Type of IDH-wildtype Glioma Characterized by Gliomatosis Cerebri-like Growth Pattern, TERT Promoter Mutation, and Distinct Epigenetic Profile
    PubMed
  • Efficacy and safety of bemcentinib in patients with advanced myelodysplastic neoplasms or acute myeloid leukemia failing hypomethylating agents- the EMSCO phase II BERGAMO trial
    PubMed
  • The multiple functions of miR-574-5p in the neuroblastoma tumor microenvironment
    PubMed
  • Patient-reported outcomes in PROSPECT trial (Alliance N1048) - FOLFOX is not a panacea
    PubMed
  • Double trouble: IRAK1/4 inhibitors in AML/MDS
    PubMed
  • Machine-Learning-Aided Prediction of Brain Metastases Development in Non-Small-Cell Lung Cancers
    PubMed
  • Active Autophagy Is Associated with Favorable Outcome in Patients with Surgically Resected Cholangiocarcinoma
    PubMed
  • Co-Expression of an IL-15 Superagonist Facilitates Self-Enrichment of GD2-Targeted CAR-NK Cells and Mediates Potent Cell Killing in the Absence of IL-2
    PubMed
  • Editorial: Translating NK cell scientific research to clinical product manufacturing
    PubMed