2024-05-27
Abkömmlinge des Contergan-Wirkstoffs treiben resistente Krebszellen in den Tod
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Pressemeldungen
2024-03-22
Neue Forschungsergebnisse – Sicherheit von kurzzeitig kultivierten CAR-T-Zellen in der Krebsimmuntherapie
Zum Artikel2024-03-07
Wirkstoffentwicklung: Deutsche Krebshilfe fördert zwei Projekte an Goethe-Universität und Universitätsklinikum mit Beteiligung von FCI-Mitgliedern
Zum ArtikelPublications
- Methylation profiling and alternative classification approaches in a glioma-enriched FFPE stereotaxic biopsy cohort
PubMed - Growing clinical evidence for successful in vivo generation of CAR T cells directed against hematologic malignancies
PubMed - Interlaboratory performance testing on EPIC v2.0 CNS tumor profiling demonstrates high reproducibility of tumor classification but reveals the need for harmonized copy number variation reporting
PubMed - Riding toward Selectivity: Optimization of Covalent 7-Azaindole-Based BMX Kinase Inhibitors
PubMed - Endothelial cytochrome P450 -derived cholesterol limits angiogenesis
PubMed - The PRECISE European initiative for cancer-vulnerability mapping and prediction
PubMed - The European Association for Neuro-oncology (EANO) Consensus Statement on Radiation Necrosis
PubMed - AI-based selection of tumor regions for genomic profiling in neuropathology
PubMed - GM-CSF downregulates type I IFN responses in glioblastoma-associated monocytes
PubMed - Patient-derived resources for decoding and targeting brain metastases ecosystems
PubMed - An in vivo platform to jointly monitor cellular and metabolic responses to chemotherapy
PubMed - Lineage-restricted dependency on an oncofetal SNHG29-IGF2BP1 RNA axis in acute megakaryoblastic leukemia
PubMed - Continuous multi-omics pathway enrichment analysis resolves hidden functional heterogeneity
PubMed - A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces cell cycle arrest and senescence
PubMed - Author Correction: MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
PubMed - Interpretable multi-omics integration across mixed-order tensors with MANTRA
PubMed - Structure-Based Design, Synthesis, and Evaluation of Novel Ponatinib Derivatives With a Significantly Altered Selectivity Profile
PubMed - Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes
PubMed - Pathogenesis of diffuse large B cell lymphoma proteogenotypes
PubMed - RNA-based full length immunoglobulin light chain sequencing reveals lambda constant domain mutations with potential implications for thermodynamic stability in light chain amyloidosis
PubMed - Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States
PubMed - Primary Mismatch Repair Deficient Glioma (PMMRDG), IDH-wildtype and H3-wildtype: A Giant Cell Tumor with Potential for Long-Term Survival Occurring at all Ages
PubMed - Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer
PubMed - Necroptosis triggers inflammatory interferon signatures in patient-derived metastatic breast cancer organoids
PubMed - MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial
PubMed - vanA-consistent phenotype vancomycin-resistant enterococcal colonization is associated with inferior overall survival in acute myeloid leukemia patients undergoing intensive chemotherapy: a single-center retrospective study
PubMed - Toward trustworthy healthcare AI: designing academic research for translation readiness
PubMed - Dual CAR-NK cells targeting PD-L1 and ErbB2 (HER2) exhibit cooperative CAR signaling and counteract solid tumor heterogeneity
PubMed - Identification of unannotated microproteins involved in endothelial cell homeostasis, dysfunction, and vascular disease
PubMed - CD155-CD96 keeps quiescent persister tumor cells in check
PubMed - Drugs that act on both G protein-coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy
PubMed - Prognostic value of DICER and CA9 expression in patients with anal squamous cell carcinoma treated with definitive chemoradiotherapy
PubMed - Emergency reversal of Rivaroxaban with Andexanet alfa in a child with hemorrhagic brain metastasis from Wilms tumor
PubMed - Fibroblast dynamics in colorectal cancer: stability, plasticity, and novel markers
PubMed - Loss of meningothelial identity and mesenchymal fate switching in NF2-mutant meningiomas
PubMed - Single cell transcriptional evolution of myeloid leukemia of Down syndrome
PubMed - Stem11 score: toward rapid clinical prognostication for acute myeloid leukemia
PubMed - In vivo characterization of the redox balance in IDH-wildtype glioblastomas: a J-difference edited MEGA-sLASER MRS study at 3T
PubMed - Treatment Patterns, Outcome, and Quality of Life of Patients With Extensive-Stage SCLC Receiving Third-Line Therapy-Data From the German CRISP Registry (AIO-TRK-0315): A Brief Report
PubMed - Endogenous protein tagging coupled with a CRISPR screening approach identifies UBE3C as a potential MYC oncogene regulator
PubMed - Multi-layered molecular profiling informs the diagnosis and targeted therapy of desmoplastic small round cell tumor
PubMed - Nuclear transcriptional condensates as drivers and therapeutic targets in NPM1-mutated AML
PubMed - Targeting glioblastoma mitochondrial metabolism with S-Gboxin induces cytotoxicity under conditions of the tumor microenvironment
PubMed - Tumor-associated epilepsy and high expression of xCT shape the proteome of IDH-wildtype glioblastoma
PubMed - Prediction of the individual risk for the development of brain metastases in patients with non-oncogene-addicted non-small cell lung cancer: Real-world data from the German prospective CRISP registry (AIO-TRK-0315)
PubMed - Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer
PubMed - Analysis of structure and conservation for supporting functional evaluation of PMS2 missense variants
PubMed - Regulation of the immune CD155-CD226-TIGIT axis by cyclin D-CDK4/6
PubMed - Inhibition of p300/CREBBP catalytic activity drives context-dependent transcriptional activation in AML
PubMed - An international multi-centre study to develop and validate federated learning-based prognostic models for anal cancer
PubMed - Fast and accessible morphology-free functional fluorescence imaging analysis
PubMed - Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease
PubMed - Ligand-based CAR design enhances durability of CD70-targeted CAR T cells in glioblastoma
PubMed - Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment
PubMed - Genetic interactions, synthetic lethality and complexity in cancer vulnerability mapping-Insights and perspectives from the 2nd EuroDepMap symposium
PubMed - Clinical and treatment-related predictors of complete response after total neoadjuvant therapy for rectal cancer in a large multicenter analysis
PubMed - Co-administered internalizing RGD peptide boosts anti-PD-L1 therapy in hepatocellular carcinoma
PubMed - Oxaliplatin-induced neuropathy after total neoadjuvant therapy for rectal cancer: Dose-response relationship and impact on quality of life
PubMed - Feasibility and safety of nintedanib in combination with nivolumab in pretreated patients with advanced or metastatic adenocarcinoma of the lung - An AIO phase Ib/II trial
PubMed - Institutional variability in testing for actionable genetic alterations in patients with stage IIIB/C or IV non-small cell lung cancer: A real-world study from the German prospective, observational, multicenter CRISP registry (AIO-TRK-0315)
PubMed - RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma
PubMed - Axes of biological variation in diffuse large B cell lymphoma
PubMed - Time to coronary angiography and revascularization in 575,247 patients with STEMI from 2012 to 2023: a retrospective population-based cohort study
PubMed - Functional connectivity in electroencephalography of brain tumor patients in status epilepticus: a retrospective evaluation of prognostic value
PubMed - New Quinoline Kinase Inhibitors With Good Selectivity for NAK Kinases and Anti-Tumor Activity Against Ewing Sarcoma
PubMed - Author Correction: Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
PubMed - PET/CT-guided management of immune checkpoint blockade and multi-modal profiling following treatment in long-term responders with metastatic lung cancer in the National Network Genomic Medicine Lung Cancer Germany (nNGM)
PubMed - p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism
PubMed - Engineering with care: safety assessment platforms for CRISPR-modified natural killer cells
PubMed - Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC-Induced Degradation
PubMed - Publisher Correction: State of the art: glioma-associated epilepsy-bridging tumor biology and epileptogenesis
PubMed - A phase III placebo-controlled study of eftilagimod alfa plus pembrolizumab and chemotherapy in metastatic non-small cell lung cancer
PubMed - ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer
PubMed - Advancing CNS tumor diagnostics with expanded DNA methylation-based classification
PubMed - Fura-10, unlike fura-2, is suitable for long-term calcium imaging in natural killer (NK) cells without compromising cytotoxicity and can be combined with target cell death analysis
PubMed - Ferroptosis Enhances T Lymphocyte Infiltration into Glioblastoma Spheroids
PubMed - Loss of global DNA hypermethylation is prognostic in IDH-mutant and 1p/19q-codeleted oligodendrogliomas
PubMed - Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells
PubMed - Study design and rationale for the NeoTRACE trial: a multicenter phase II study of neoadjuvant sacituzumab govitecan plus zimberelimab followed by adjuvant zimberelimab with or without sacituzumab govitecan in patients with resectable non-small cell lung cancer
PubMed - A masking clamp for conditional activation of therapeutic antibodies
PubMed - Allele-specific immune gene quantification and expression analysis in single-cell RNA-seq data
PubMed - ApoE2-DARPin fusion proteins enable selective RNA transfer to CD8 T cells by lipid nanoparticles
PubMed - Impact of preoperative clinical patient parameters on surgically obtained brain metastasis samples for translational research
PubMed - HDR Mould-Based Brachytherapy for Cutaneous Neoplasms: Toxicity, Long-Term Control, Cosmesis and PROMs
PubMed - Lung endothelial PEAR1 induces tumor cell dormancy
PubMed - Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
PubMed - Mesenchymal thymic niche cells enable regeneration of the adult thymus and T cell immunity
PubMed - Rethinking survival metrics in EGFR-mutated NSCLC: insights from RMST analysis of FLAURA2 and MARIPOSA
PubMed - Measurable residual disease-guided interventions in patients with acute myeloid leukaemia undergoing allogeneic haematopoietic cell transplantation: best practice recommendations from the European Society for Blood and Marrow Transplantation Practice Harmonisation and Guidelines Committee
PubMed - Targeting Mutual Dependence of Phosphatidylinositol-3-Kinase α/δ and Small Ubiquitin-Like Modifier Signaling in Pancreatic Cancer
PubMed - Quality of life following total neoadjuvant therapy for rectal cancer
PubMed - Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures
PubMed - A Chemically Induced CRISPR/dCas13FCPF Platform for Precise and Programmable RNA Regulation
PubMed - Insights, opportunities, and challenges provided by large cell atlases
PubMed - Outcomes at Patient and Limb Levels in Peripheral Artery Disease by the Location of Atherosclerotic Lower Limb Lesions: An Observational Study from a High-Volume German Center
PubMed - Short-course radiotherapy versus long-course chemoradiotherapy in total neoadjuvant therapy of rectal cancer - A multicenter analysis of early outcomes and toxicity
PubMed - State of the art: glioma-associated epilepsy-bridging tumor biology and epileptogenesis
PubMed - Glioma‑associated microglia and macrophages as a potential target for mTOR inhibition in glioblastoma
PubMed - Current and emerging concepts for systemic treatment of metastatic colorectal cancer
PubMed - Hypomethylating Therapy With or Without Eltrombopag in Elderly Patients With Acute Myeloid Leukemia: Results From the Randomized, Placebo-Controlled Phase 2 DELTA Trial
PubMed