Manuel Kaulich

FCI Professur Autophagie in der Tumorpathogenese

Research Focus:

Expertise and Technologies for FCI:

Core Publications

Publications

  • Genetic interactions, synthetic lethality and complexity in cancer vulnerability mapping-Insights and perspectives from the 2nd EuroDepMap symposium
    PubMed
  • Author Correction: Multi-scale classification decodes the complexity of the human E3 ligome
    PubMed
  • Multi-scale classification decodes the complexity of the human E3 ligome
    PubMed
  • BaCoN (Balanced Correlation Network) improves prediction of gene buffering
    PubMed
  • Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy
    PubMed
  • Long-noncoding vulnerabilities in MM
    PubMed
  • Targeted protein degradation via intramolecular bivalent glues
    PubMed
  • Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis
    PubMed
  • The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension
    PubMed
  • ReCo: automated NGS read-counting of single and combinatorial CRISPR gRNAs
    PubMed
  • Deciphering the mitophagy receptor network identifies a crucial role for OPTN (optineurin) in acute myeloid leukemia
    PubMed
  • Optimized metrics for orthogonal combinatorial CRISPR screens
    PubMed
  • FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels
    PubMed
  • USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
    PubMed
  • Protein import motor complex reacts to mitochondrial misfolding by reducing protein import and activating mitophagy
    PubMed